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The use of cDNA libraries to demonstrate a linkage between transcription and translation in male germ cells. The [.. ED is a symptom, not a disease and will have underlying causes such as hypertension, coronary artery disease, diabetes, chronic renal impairment, chronic arthritis, chronic alcoholism, multiple sclerosis.

This book will be an essential reference for family practitioners and residents in urology. Features Concise guide to erectile dysfunction and its management for family practitioners and residents Contents Introduction. Erectile dysfunction aetiology and risk factors. VIII, 94 illus. Wallace, St. Nursing Care of the Pediatric Neurosurgery Patient "Nursing Care of the Pediatric Neurosurgery Patient" serves as a detailed reference for all nurses caring for children with neurosurgical problems.

Staff nurses and student nurses working in clinics, PICU, pediatrics, operating rooms, post-anesthesia care units, emergency department and radiology will benefit from the information presented in this book. The explanations of pathophysiology, anatomy, radiodiagnostic testing and treatment options for each neurosurgical diagnosis will help them to understand the rationale behind the nursing care. Presenting symptoms and findings on neurological examination and history will enable nurses to identify normal signs.

Each chapter includes information on patient and family education and will give helpful guidelines. Although there has been a need within the pediatric neurosurgery community for this type of information for years, there is no other reference available that provides this type of specific information. Features Complete pediatric neurosurgical nursing reference Helps understand the rationale behind the nursing care Helps identify actual symptoms Includes information on patient and family education and 'pediatric perls' Clear and standardized chapter structure Contents Neurologial Assessment of the Neonate, Infant, Child and Adolescent.

Chang, Seoul, Republic of Korea; K. Cherry, St. Iltis, Saint Louis University, St. Proceedings Recent developments in regional and systemic anticancer therapies have improved the grim outlook of patients with peritoneal carcinomatosis PC from ovarian or gastrointestinal origin, leading to a renewed interest in both the underlying mechanisms at the origin of PC and the various therapeutic options.

This is the first volume to provide a multidisciplinary approach to peritoneal carcinomatosis encompassing molecular mechanisms, histopathology, regional and systemic cytotoxic therapy, and surgical options. Peritoneal Carcinomatosis: A Multidisciplinary Approach will be of interest for medical, surgical and gynecological oncologists faced with the complexities of decision making in patients suffering from PC, as well as for basic and translational scientists active in the field of locoregional cancer spread.

Numerous illustrations aid the reader throughout in the many facets of this disease. Features Peritoneal Carcinomatosis encompasses basic and molecular mechanisms, histology, local and systemic cytotoxic drug therapy, and surgical strategies Foreword by Paul H. Part 1. Peritoneal Carcinomatosis: Basic Concepts. Nonoperative and Multimodal Management of Peritoneal Carcinomatosis.

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Experimental Approaches. XXXI, p. Cancer Treatment and Research, Band Geb. More than 50 speakers with world-famous reputations from 12 countries come together to a total of 52 topics on recent developments in Bioceramic and alternative bearings in arthroplasty. Among the recent developments in the arthroplasty field, bearing surface occupies one of the most important positions. In Asian culture, sitting with crossed legs and squatting positions are more common compared to the Western culture.

Because of such a different cultural background, in arthroplasty, impingement and wearing of liner are more important problems. With this point of view, the interest about bioceramic and alternative bearing is increasing. The written version of the scientific program will allow you to carry home a more concise view of the Symposium presentations. Features The most up-to-date information regarding the use of ceramic solutions Contents Tribology. Brody has been one of the most important voices in bioethics over the last several decades, asking new and challenging questions about a range of problems, examining recalcitrant issues in novel ways, always with the goal of offering practical solutions to complex problems.

Done well, philosophical work can clarify complex issues, facilitate creative problem solving, and lead to real-world solutions to difficult situations. Each contributor [.. XIX, p. XII, p. Philosophy and Medicine, Band 94 Geb. This volume, part of the Essentials in Cytopathology book series, fits into the lab coat pocket and is ideal for portability and quick reference. Each volume in the series is heavily illustrated with a full color art program, while the text follows a user-friendly outline format.

Features Published in the Essentials in Cytopathology book series Designed to be concise and easy to use Fits in lab coat pocket Site specific Majority of illustrations are in four color Illustration oriented accompanied by text in outline format Contents Introduction Pancreas Pathology and Diagnosis. Pancreatic Endocrine Tumors. Ancillary Testing and Future Directions. The process of emergence is conceptualized as two transition stages which are common and required for all disease emergence, 1 human contact with the infectious agent and 2 cross-species transmission of the agent, and two transition stages which are not required for emergence and appear unavailable to many zoonotic pathogens, 3 sustained human-tohuman transmission and 4 genetic adaptation to the human host.

The latter two transitions are presumably prerequisites for the pandemic emergence of a pathogen. The themes introduced herein are amplified and explored in detail by the contributors to this volume. Each author explores the mechanisms and unique circumstances by which evolution, biology, history, and current context have contrived to drive the emergence of different zoonotic agents by a series [..

VII, p. Each chapter includes specific case presentations representative of the most commonly treated conditions, including applications for spinal disorders. Chapters conclude with counterpoint experiences, oriented to treatment options other than radiosurgery i. These counterpoint discussions are written by noted experts and address in greater detail the indications, results and complications of their approach and enable readers to improve decision making with regard to choosing treatment options for their own patients.

Also included is information on important non-surgical aspects of radiosurgery, including site construction, regulatory and billing issues, legal concerns, and nursing care issues. The editors have treated over patients using this technology, and [.. Metastatis Brain Tumors. Arteriovenous Malformations. Prostate Cancer Medizin S. The latest edition contains new material on molecular imaging, new treatments for prostate cancer, molecular targets, cell signaling pathways, bioinformatics, and pathogenomics.

The book details the latest innovations and advances in prostate cancer and may be used as a rapid reference text for readers. The volume profiles the latest advances in cancer research and treatment and includes profound studies in prostate stem cells, cancer-host interactions, hedgehog signaling in development and cancer, cholesterol and cell signaling, gene therapy for advanced prostate cancer, and noninvasive strategies such as molecular imaging to visualize gene expression.

This new edition also investigates expression profiling and somatic alterations in prostate cancer progression and linkage studies of prostate cancer families to identify susceptibility genes. Wie ist vorzugehen? Preface - to be submitted. Biology and Imaging. Cancer-host interactions: A paradigm shift brings new understanding and new opportunities. Klassifikation des Diabetes mellitus. Schwangerschaft, Entbindung und die Besonderheiten bei Diabetes mellitus.

Contemporary Cancer Research Geb. Each chapter has been written by an expert renowned in his or her field and been reviewed by a second expert. All of the approximately illustrations have been drawn by the same team of three artists of notable experience. In this atlas experts of upper abdominal surgery share their experience and show how they do it - step by step. Features Abundantly illustrated atlas describing the state of the art techniques for key procedures of the upper abdomen Each procedure is associated with a short comment regarding indications of the various operative steps Internationally renowned experts describe and illustrate the various procedures step-by- step Contents Section 1 Introduction.

Subject Index. In Part 1, detailed descriptions, photographs, and diagrams illustrate each major surgical procedure and variations. Part 2 presents an extensive review of surgical complications including their prevention, recognition, and treatment. The text is lavishly illustrated with artwork and photographic examples, and well-supported by sample references. Thus, the reader will benefit highly from expert stepby-step instructions on how to perform both basic and complex strabismus surgery and how to avoid, recognize, and treat strabismus surgery complications.

Features Expert step-by-step instruction on how to perform both basic and complex strabismus surgery Excellent artwork diagrams and photographs demonstrating surgical techniques and potential complications Single source reference to learn about potential strabismus surgery complications and how to avoid, recognize, and to treat them Written by well-known experts DVD with video-clips of surgical procedures plus [.. Surgical Equipment and Operating Room Supplies.

Techniques of Exposure and Closure. Adjustable Suture Techniques. It meets the needs of doctors not covered by their training e. Communication skills, coping and adjustment in pregnancy, communicating with cancer patients. Chapters show how to use the consultation to maximum benefit for the patient and doctor. Easy-to-read with stand-alone chapters, this book covers key aspects of O and G, and addresses areas not covered in other texts. It is relevant to all stages of O and G practice - from trainees to consultants and some lay interest.

This book offers topics in psychological care to trainees and specialist in O and G, helps them understand the emotional problems their patients face, and shows them how to undertake psychological care. Features Easy-to-read format Broad overview Demystifies the psychological aspects of the subject, making it easier to integrate psychological aspects into practice A more holistic approach improves the care for women Enables the doctor to make consultations more effective despite the limitations of time Contents Teaching psychosomatic obstetrics and gynecology.

Coping and adjustment in pregnancy: giving babies a better start. Post-traumatic stress disorder. With DVD. The 19 revised full papers presented together with 2 keynote talks were carefully reviewed and selected from 52 submissions. The papers adress all current issues in data integration and data management from the life science point of view and are organized in topical sections on new architectures and experience on using systems, managing and designing scientific workflows, mapping and matching techniques, modeling of life science data, and annotation in data integration.

Also available online. Therapeutic Uses of Botulinum The Statistical Analysis of Recurrent Toxin Events Recurrent event data arise in diverse fields such as medicine, public health, insurance, social science, economics, manufacturing and reliability. The purpose of this book is to present models and statistical methods for the analysis of recurrent event data. No single comprehensive treatment of these areas currently exists. The authors provide broad but detailed coverage of the major approaches to analysis, while also emphasizing the modeling assumptions that they are based on.

Thus, they consider important models such as Poisson and renewal processes, with extensions to incorporate covariates or random effects. More general intensity-based models are also considered, as well as simpler models that focus on rate or mean functions. Parametric, nonparametric and semiparametric methodologies are all covered, with clear descriptions of procedures for estimation, testing and model checking. Observation schemes giving incomplete or selective data.

The editors explore how this novel compound fits into a wide variety of treatment algorithms across medical subspecialties. Each chapter focuses on a particular symptom and explains how botulinum toxin is currently used for treatment. The chapter authors are all leaders in their fields and are respected for their progressive approach to treatment. Physicians will benefit not only from those chapters devoted to their particular sub-specialty, but from the inspiring success resulting from the use of botulinum toxin in other patient populations.

The concluding chapter examines questions of immunity, explores economic issues, and attempts to forecast future directions for this novel and somewhat mysterious drug. Clinicians across a wide variety of disciplines will refer to this comprehensive reference time and time again. Features Defines our current understanding of botulinum toxin and its method of action Presents therapeutic uses across a variety of medical subspecialties and patient populations Encourages responsible research into new and novel uses of botulinum toxin Contents From the contents 1.

History and Mechanism of Action. Back Pain. Piriformis Syndrome. Plantar Fasciitis. Spasmodic Dysphonia. Sialorrhea and Frey's Syndrome. Cosmetic Applications. Urologic Applications. Economics, Immunity, and Future Directions. Arthritis Research Volume 1: Methods and Protocols Arthritis Research: Methods and Protocols is a compendium of data pertinent to the methods and protocols that have contributed to recent advances in molecular medicine in general, but to the molecular basis of rheumatic disease in particular.

These volumes details novel technologies, some of which are still evolving and whose impacts are yet to be determined. Leaders in the field contribute to cover such exciting and cutting edge topics as imaging and immunohistochemistry, analysis of cartilage and bone catabolism, immunobiology, and cell trafficking.

In Volume 1, authors discuss synovial joint morphology, histopathology, and immunohistochemistry, cartilage matrix and bone biology, and cell trafficking, migration and invasion. Both [.. Synovial Joint Morphology, Histopathology, and Immunohistochemistry. Imaging Inflamed Synovial Joints. Arthroscopy as a Research Tool: A Review. Immunohitochemistry of the Inflamed Synovium. In Situ Hybridisation of Synovial Tissue.

Subtractive Hybridization. Preparation of Mononuclear Cells from Synovial Tissue. Quantitative Image Analysis of Synovial Tissue. Cartilage Matrix and Bone Biology. Cartilage Histomorphometry. Image Analysis of Aggrecan Degradation [.. Due August Statistics for Biology and Health Geb.

Gilbert, The University of Texas M. Mahajan, The University of Texas M. Tumors of the Brain and Spine Arthritis Research: Methods and Protocols is a compendium of data pertinent to the methods and protocols that have contributed to recent advances in molecular medicine in general, but to the molecular basis of rheumatic disease in particular.

Analysis of Antigen Reactive T Cells. Assay of T Cell Contact [.. The conference embraced low power and high power techniques, including noninvasive tissue ablation for cancer therapy, treatment of stroke, haemostasis, ultrasound-enhanced drug delivery and gene therapy. Topics discussed include: Therapeutic ultrasound; ultrasound calibration; dosimetry; exposimetry; ultrasound field characterization; ultrasound transducers, high-intensity focussed ultrasound HIFU ; acoustic haemostasis; thrombolysis; heating; hyerpethermia; ablation; acoustic cavitation; inertial cavitation; stable cavitation; treatment guidance; magnetic resonance imaging MRI ; tissue phantoms; liver kidney prostate cancer; sonodymamic therapy; ultrasound contrast agent; targeted drug delivery; microbubbles; liposome; nanoemulsion; sonoporation; sonotransfection; gene transfer; gene delivery; transcranial; blood-brain [..

Anderson Cancer Center. It is written mainly for the primary care oncologist, general neurologist, and general neurosurgeon. Chapters on treatment focus on neurosurgery, chemotherapy, and radiation therapy, both singly and in combination. Chapters on symptom management, the molecular genetics and neuropathology of intracranial tumors, the leptomeningeal dissemination of systemic cancer, the epidemiology of brain tumors, and innovative treatment strategies round out the volume.

Reviews symptom management, molecular genetics and neuropathology of intracranial tumors, leptomeningeal dissemination of systemic [.. Therapeutic Neovascularization — Quo vadis? The volume "Therapeutic Neovascularization: Quo Vadis? It meets an at times urgent need for treatment of patients who otherwise are not suitable for the established routines of percutaneous and surgical revascularization. At present most of the clinical trials initiated to promote neovascularization of ischemic myocardial or peripheral muscle tissue have failed to provide significant improvement of prespecified endpoints.

This collection of manuscripts is selected to provide the most recent developments improving the auspices of successful revascularization therapy. Therefore, it covers sections such as the clinical challenge, novel mechanical and molecular concepts and cell therapy as an option, each composed of chapters written by experts in their fields. This collection of current and future concepts of neovascularization offers [.. X, 62 S. Ein reichhaltiges Bildmaterial rundet diese historische Darstellung ab. Each chapter takes a step-by-step approach to this emerging technology, from basic principles of instrumentation, imaging, and protocols, to advanced discussions of current and future clinical applications.

Perspective on other emerging imaging modalities e. Molecular imaging approaches that are likely to play a clinical role in the future are also thoroughly covered. Instrumentation and Principles of PET. Chapter 2: Patho-physiology of Imaging. In clinical practice, radiologists play a key role in the assessment of small bowel obstruction and can guide physicians toward appropriate and timely management of the many indeterminate cases and situations.

However, to understand and connect the pathophysiology to the imaging features remains the most difficult task radiologists face in their clinical activity. The aim of this book is connect pathophysiology to imaging using many illustrations and examples, emphasizing the capabilities and limitations of multidetector computed tomography and its role in the correct management approach to these disorders. Furthermore, the place of allied imaging modalities plain film and ultrasound in the clinical algorithm is comprehensively illustrated.

Target groups Radiologists and residents, nuclear cardiologists and residents, cardiologists and residents, nuclear physicians and residents Due May The reagent exhibits remarkable regio-, chemo-, and stereoselectivity during hydroboration reactions. Diels-Alder and Suzuki reactions have expanded the utility of 9BBN for the synthesis of a variety of organic compounds required for industry.

Consequently, this vast field in the form of a book will be helpful to synthetic organic chemists for easy access to literature, required for chemical transformations. Di Mizio, S. Pasquali, S. It provides upto-date information on new developments in the field of chronic hepatitis and its various entities. In recent decades we have learned how heterogeneous the clinical entity of chronic hepatitis has become.

The liver, as the central organ of metabolism and detoxification, is more than ever a target of disease processes evolving from the spread of obesity in the western world. Apart from nonalcoholic steatohepatitis NASH , alcoholic liver disease is still the most prevalent liver disease in the west. Alcohol-induced liver disease exhibits a broad clinical spectrum from alcoholic steatohepatitis to cirrhosis.

Alcoholic hepatitis is a disease entity with a particular poor prognosis. Any liver disease of unknown cause is suspected as being [.. The resultant problems with unwanted side effects are compounded by difficulties in predicting the desired effectivity of chemotherapy in individual patients. This unsatisfactory situation has driven intensive research and development towards more specific and less toxic anticancer drugs over the last few decades.

Several results of these efforts have reached the clinic and an even greater number are now in preclinical testing. Common to all these targeted therapies is their interaction with defined molecules present on cancer cells, which adds various degrees of increased selectivity to their toxic effects. As a consequence, detecting the target molecule on tumors before therapy holds great diagnostic potential for predicting the efficacy of the drug and personalizing [..

Cytostatic drug resistance and new anti-cancer targets. Neoadjuvant chemotherapy in carcinomas of the upper gastrointestinal tract. Resistance-associated signatures in breast cancer. Resistance to chemotherapy in ovarian carcinoma. Metastasis in colorectal cancer. Chemotherapy in colorectal cancer. Proteomic expression profiling of breast cancer.

Targeted therapy and blood-brain-barrier. Cetuximab — appraisal of a novel drug against colorectal cancer. Type of publication Monograph Features Interdisciplinary symposium bringing together basic science and clinical applications. Contemporary Endocrinology Geb. Die Notfallmedizin springer.

Die ideale Kombination aus Hintergrundwissen und praxisrelevantem "Know how"! Serruys, who pioneered the use of drug-eluting stents, and other pioneers in the field cover everything from non-invasive imaging, to eluting stents, to brachytherapy through to the latest molecular biology-based treatments including antisense, stem cells and gene therapy, making this an essential reference for all interventional cardiologists.

Features Gold-standard reference on the treatment of restenosis for interventional cardiologists Produced by leading interventional cardiologists, including Patrick Serruys, Eric Topol, David Holmes, and Thomas Luscher Contents Epidemiology and Pathogenesis of Restenosis. Gene Expression Profiling and Restenosis. Bewusst werden alle Berufsgruppen, die an der Versorgung dieser Patienten beteiligt sind, angesprochen.

Funktionelle Auswirkungen auf den Bewegungsapparat. Contemporary Cardiology Geb. XIV, S. Based on contributions by experts from NATO member states, Israel and the Russian Federation, this book offers information on fourth generation warfare as a new challenge to first responders. Furthermore, the book offers solution for restoring the community to functioning after such a major terror attack. Topics include preparing, planning, operations, equipment, training and unique applications of existing technologies for countering terrorist attacks against cities and their infrastructure.

International terrorism remains a significant threat to the peace of the world. Weapons using various materials and delivery systems have been directed against cities and infrastructure, and other materials are postulated to be usable within the near future. Some of these materials are unusual or exotic, while some are modifications of materials used daily for other purposes: biological, chemical, radiological, nuclear and explosive. These materials pose a safety challenge for first responders, slowing the response and potentially killing scarce trained personnel.

The issue. Emergency planning and terrorism. The framework. Security threat assessment. Preparing for natural hazards vs. The new risk environment. Unconventional use of conventional explosives. Radiological weapons. Weapons of mass destruction. Emergency management challenges. Challenges to law enforcement due to a major terror attack. Challenges due to NRBC threats. Covert versus overt terror attack. Response by law enforcement agents. Prevention and disruption by law [.. Heterocycles from Carbohydrate Precursors Features Heterocyclic chemistry is the biggest branch of chemistry covering two-third of the chemical literature Covers hot topics of frontier research summarized by reputed scientists in the field Topic related Online version available on SpringerLink.

El Ashry, Y. El Kilany, N. Furman, Z. Kaluza, A. Stencel, B. Grzeszczyk, M. Cavaleiro, J. Faustino: Synthesis of [.. Topics in Heterocyclic Chemistry, Band 7 Geb. Medizin B. Die Phakomatosen. Autoimmune und toxisch bedingte Erkrankungen. Hydrozephalus im Kindesalter. Traumatische Erkrankungen des kindlichen Gehirns. Hirntumoren im Kindesalter. Interdisciplinary and integrated evaluations, treatment, and management can mean the difference between successful recovery and unfortunate outcomes.

XVII, S. A generation ago, the management of patients with urinary stones was forever altered with the introduction of minimally invasive treatment techniques such as shock wave lithotripsy, ureteroscopy, and percutaneous stone removal. We are again in the cusp of revolutionary developments in the management and prevention of nephrolithiasis. This conference featured a very distinguished international faculty whose present research is clearly advancing the field of stone disease.

This conference marked the first presentation of data on the interface between a renal stone and its tissue attachment site. Immunological Tolerance Methods and Protocols Immunological Tolerance: Methods and Protocols is a comprehensive guide to the techniques currently used for culturing and characterising the cell types responsible for imposing self-tolerance and the experimental models employed to study their function both in vitro and in vivo.

Features Provides up-to-date reviews of the literature on essential topics in immunological tolerance Documents methods for the generation and culture of critical cell types and approaches to their characterization Describes protocols for the study of tolerance both in vitro and in vivo Provides insights into novel techniques for tolerance induction Contents From the contents Frontiers of Immunological Tolerance.

Adipose Tissue and Adipokines in Health and Disease The aim of Adipose Tissue and Adipokines in Health and Disease is to provide comprehensive information regarding adipose tissue, its physiological functions and its role in disease. This volume contains a collection of information spanning the entire range of adipose tissue studies, from basic anatomical and physiological research to epidemiology and clinical aspects, in one place.

This book is indispensable for basic researchers and clinicians interested in the fields of obesity, metabolic diseases, inflammation and immunity, and specialists in each of the pathologies associated with obesity. Features Provides a comprehensive review of fundamental adipose tissue anatomy and physiology Introduces a novel and dynamic model for adipose tissue study Examines vasoactive and inflammatory molecules produced by adipose tissue Describes the role of macrophages in obesity and metabolism Discusses the interaction between adipocytes and hematopoietic cells in bone marrow Analyzes the metabolic disturbances associated [..

Adiponectin and Inflammation. Nutrition and Health Geb. Panoramic Radiology Seminars on Maxillofacial Imaging and Interpretation Panoramic radiology systems are currently being used in more practices than at other any time in the past. The practitioner now has decisions to make regarding detector technology selection for image acquisition and must remain informed about appropriate usage. This book is applicable to all panoramic dental images and equipment. It approaches panoramic radiology usage in the context of general and specialty applications.

Features Complete up-to-date collection of information on panoramic radiography usage Up do date Terminology and validated by representatives of individual special disciplines within dentistry Each chapter with educational objectives and review Questions Contents Getting the Most out of Panoramic Radiographic Interpretation. Handbuch diagnostische Radiologie Geb. Neurodegeneration in Multiple Sclerosis In multiple sclerosis MS , conventional magnetic resonance imaging cMRI has proved to be a valuable tool to increase diagnostic confidence and for monitoring the efficacy of experimental treatment.

However, cMRI has limited specificity and accuracy of cMRI to the most disabling aspects of the MS pathology, known to occur in and outside macroscopic lesions. Modern quantitative MR techniques have the potential to overcome the limitations of cMRI, and their application is changing dramatically our understanding of how MS causes irreversible disability.

In detail, there is an increasing body of MR evidence that MS is not only a white matter disease and does not only cause focal lesions, as well as that neurodegeneration is an important aspect of the disease since the earliest clinical phases , which is only partially related to inflammatory changes. There is also increasing perception that modern MR methodologies should be more extensively employed in clinical trials to derive innovative [..

Topics in Neuroscience Geb. Complications of Regional Anesthesia Completely updated and expanded, this new edition of "Regional Anesthesia: Managing Complications", 2nd edition is essential reading for advice on the prevention and management of complications associated with regional anesthesia and nerve blocks. In addition to comprehensive coverage of all potential pitfalls a practitioner may encounter, new material has been added comparing outcomes of regional and general anesthesia; regional anesthesia in the anesthetized patient; closed claims analyses; and practice guidelines to ensure patient safety.

Features New revision of a significant text on the topic of preventing and managing complications associated with regional anesthesia and nerve blocks Contents An historical perspective on complications of regional anesthesia. Complications of spinal anesthesia. Twelve Lead Electrocardiography for ACLS Providers deals solely with the analysis of the shape morphology of ECG waveforms in order to diagnose many conditions not related to rhythm, including ischemia, acute myocardial infarction, and enlargement of heart muscle hypertrophy.

It is aimed at students who already have a familiarity with the analysis of heart rhythms. Almost all other texts of morphologic interpretation for non-cardiologists rely heavily on memorizing electrocardiographic patterns.


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Memorizing is difficult, and long term retention of memorized data is low. This book is unique because it leads the reader through a set of discrete building blocks of easily understood electrophysiologic principles, and then allows the reader to deduce what the 12 lead electrocardiogram will look like under various circumstances.

There [.. Positiv therapieren! Derivation of the Normal Electrocardiogram. Myocardial Infarction. Softcover Due September Originally published by W. Saunders Company, Priewe, D. Das Erste - kompakt springer. Furberg, Kungsbacka, Sweden; C. Der Frank-Sterling-Mechanismus? Staatsexamen brauchen. Staatsexamen sind? Fields of interest Medicine, general Target groups Medizinstudenten in der Vorklinik Type of publication German textbook The objective of this book is to make its readers better informed and more critical consumers of clinical research to help them recognize the strengths and the weaknesses of scientific publications.

In doing so, the reader will be able to distinguish patient-important and methodologically sound studies from those having limitations in design, conduct and interpretation. There are no prerequisites for reading this book. The text is basic and has no statistical formulas. Key take-home messages are listed at the end of each chapter. The large number of cartoons has two purposes: First, to make the text easier to read and generate a few laughs and, second, to underscore specific points, sometimes in a provocative way.

Features Updates and expands the first edition of this text, released in The previous edition was only available in Swedish Contents What is the Purpose of This Book?. V, p. Starting from the dual premises that a population is not merely the sum of its individuals and that the improvement of population health is not at odds with the practical desire of improving the health of individuals, Sandro Galea and 33 expert contributors present chapters in three sections. The first section includes eleven chapters that each discuss one macrosocial determinant of population health.

The factors covered by these chapters encompass a broad range of intellectual concerns, ranging from regulations and legal frameworks global governance, patent law and policy , to overarching global phenomena globalization, migration, urbanization, the media , to a specific consideration of the role [.. Section I: Determinants. Global governance. Kildare, Ireland; M. Psychoprosthetics Psychoprosthetics brings together, into one easily accessible volume, the most recent and exciting research and knowledge in this new field.

Psychoprosthetics is defined as the study of psychological aspects of prosthetic use, and of rehabilitative processes in those conditions that require the use of prosthetic devices. Features Compiles the most recent research and knowledge of Psychoprosthetics into one accessible volume Contributions from well-known clinicians, practitioners, researchers and academics who work with prosthetics Contents Psychoprosthetics: An introduction.

Cancer Survivorship 37 R. The Papillomaviruses Today and Tomorrow There are now million cancer survivors in the United States alone up from 3 million in Multiple studies have shown that most survivors today were diagnosed more than 20 years ago. As this former patient population ages, the relationships between secondary malignancies, age-related onset of certain malignancies, and screening and prevention become increasingly important, not only to the patient population, but also to the cancer management team treating the patients.

There are multiple resources available to serve as oncology textbooks, but nothing to provide the necessary information on patient care for the non-MD members of the cancer patient management team. Cancer Survivorship provides the necessary information about not only the clinical aspects of caring for survivors, but also the psychosocial impacts.

In the post-treatment phase, the management team must go beyond the realm of "conventional" follow-up, helping the patient to intellectually understand and emotionally grasp the [.. Surveillance after Primary Therapy. To date, more than 70 HPV types have been identified, of which over 15 have been reported in cervical cancer biopsies.

Although investigations of cervical cancer are most abundant, the report also considers the possible involvement of HPV infection in cancers at other site of the human body. The rapid advances in papillomavirus biology and vaccine development have surpassed all current summaries of the field. Features Complete description of the current state of biology concerning the papillomavirus Contents Principles of Human Tumor Virology.

Papillomavirus Structure and Assembly. Jahrhunderts mit enormem wirtschaftlichem Potenzial. Physikalischchemische Grundlagen werden ebenso behandelt wie Fragen der Ethik, der Risikokommunikation, des Umweltschutzes, der Gesundheit, des Regulationsund Forschungsbedarfs sowie wirtschaftliche und gesellschaftliche Aspekte. Gatterer, Geriatriezentrum am Wienerwald, Wien Ed. Multiprofessionelle Altenbetreuung Ein praxisbezogenes Handbuch Die Altenbetreuung wird in diesem Handbuch aus der Sicht von unterschiedlichen Fachdisziplinen umfassend vorgestellt.

Krankheiten [.. XIV, mit 35 Abb. XIX, S. Teil 4 des Radiologie-Bestsellers! Der radiologische Bestseller ist neu aufgelegt und aktualisiert. Die komplette Serie umfasst folgende Titel: 1. Radiologie Technik 2. Bewegungsapparat 4. Abdomen 6. Read more Read less. Kindle Cloud Reader Read instantly in your browser. Not Enabled. No customer reviews.

Share your thoughts with other customers. Write a customer review. Amazon Giveaway allows you to run promotional giveaways in order to create buzz, reward your audience, and attract new followers and customers. Learn more about Amazon Giveaway. This item: 4. Set up a giveaway. Taken together, our results suggest that B. Carcinogenic human papillomaviruses HPV cause the majority of cervical cancers and other anogentical cancers.

Large randomized trials have shown that HPV testing can be efficiently used for primary cervical cancer screening. Other applications include the triage of abnormal cytology results and the follow-up of women after treatment. The various tests can have very different applications. It is important to validate HPV assays before they are implemented in screening or clinical care. Dick Potsdam and J. Hamel Berlin. Besides a few short notices and book reviews, the book contains eight major articles, which deal with astronomical topics covering the time from the 16th to the 19th centuries.

The first article by Michael Weichenhan Berlin deals with "the invention of the disk-shaped earth: a chapter of Copernican apologetics". The author shows that the concept of a "disc-shaped Earth" was by no means widespread in the middle ages, but restricted to the father of the church Lactantius and some adherents.

Nevertheless, it was used by adherents of Copernicus to show the absurd consequences of a strictly literal biblical interpretation -- here concerning the Earth's shape, disc versus sphere, there the geocentric versus the heliocentric system. This thorough philosophical study is followed by two very short articles. The result is that standard deviations are 80 arcseconds for Saturn and 89 arcseconds for Jupiter and Mars, an unexpectedly poor result in view of the general opinion that Tycho was famous for his precision work.

While he was inclined to Galilei early on, he was forced to propagate Aristotelian doctrine. The brief article is very concise, but extremely tiresome to read 3 pages of pure text are embellished by. Die Leitlinie stellt allgemeine Aspekte der Pharmakokinetik sowie der regulatorischen Begrifflichkeiten dar. Die Bedeutung der galenischen Grundlagen und die Problematik bei einer Substitution gegeneinander verschiedener Grundlagen werden dargestellt.

In various bacteria, Zur , a zinc-specific regulator of the Fur family, regulates genes for zinc transport systems to maintain zinc homeostasis. It has also been suggested that Zur controls zinc mobilization by regulating some ribosomal proteins. The antibiotic-producing soil bacterium Streptomyces coelicolor contains four genes for Fur family regulators, and one named zur is located downstream of the znuACB operon encoding a putative zinc uptake transporter.

Purified Zur existing as homodimers bound to the znuA promoter region in the presence of zinc, confirming the role of Zur as a zinc-responsive repressor. This finding reflects a link between thiol-oxidizing stress and zinc depletion. We determined the Zur -binding sites within znuA and rpmG2 promoter regions by footprinting analyses and identified a consensus inverted repeat sequence TGaaAatgatTttCA, where uppercase letters represent the nucleotides common to all sites analyzed. This sequence closely matches that for mycobacterial Zur and allows the prediction of more genes in the Zur regulon.

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Vor diesem Hintergrund wird das auf dem ganzheitlichen St. English Title: Attempts to produce catalytic antibodies for hydrolysis of arylcarbamates and arylureas. Es wurden verschiedene Hapten-Protein-Konjugate unter Verwendung unterschiedlicher Kopplungsmethoden hergestellt und charakterisiert. Diese Werte korrelieren mit den Werten der wenigen bekannten Diphenylcarbamat-spaltenden Abzyme.

Dies beweist, dass die Hydrolyse in der Antigenbindungsstelle stattfindet. Born in Gelsenkirchen-Buer in Germany on March 11th, , Professor Harald zur Hausen, Emeritus Professor of Virology at the University of Freiburg and Nobel Prize Laureate in Physiology or Medicine for his discovery of human papillomavirus HPV , which causes cervical cancer, believes that good knowledge of virological methods and diagnostic possibilities are an asset for all young paediatricians. Professor zur Hausen considers that the creation of an educational platform on Paediatric Virology is definitely very beneficial for young paediatricians, as this will greatly enhance their knowledge in the field of Virology.

He very actively advocates the vaccination of boys for the eradication of HPV infection and emphasises that male HPV vaccination should be included into the current vaccination programmes. He would have certainly considered Dr George N. In the context of the 3rd Workshop on Paediatric Virology, which will be held in Athens, Greece, on October 7th, , Professor zur Hausen will give his plenary lecture on 'Paediatric Virology and Oncology: Virus persistence and the important first years of life'.

Sowohl humane, als auch murine in vitro generierte dendritische Zellen lassen sich mit MVA — im Vergleich zu anderen viralen Vektoren — sehr gut infizieren. Nur in dieser Kombination werden sich nachhaltig Wettbewerbsvorteile generieren lassen. Manch ein Kunde wird die Lust, einen Prozess zu Ende zu gehen, schon vor dem Abschluss verlieren, wenn er nicht unmittelbar und ohne die digitale Welt zu verlassen zum Ziel kommt. Die Behandlungsgruppe zeigte bei beiden Werten eine Verbesserung von klinischer Relevanz. Karger GmbH, Freiburg.

Die Architektur besteht aus mehreren dedizierten Recheneinheiten zur parallelen Verarbeitung rechenintensiver Bildverarbeitungsverfahren und ist mit einem RISC-Prozessor verbunden. This paper presents the mapping of a video-based approach for real-time evaluation of angular histograms on a modular coprocessor architecture.

The architecture comprises several dedicated processing elements for parallel processing of computation-intensive image processing tasks and is coupled with a RISC processor. A configurable architecture extension, especially a processing element for evaluating angular histograms of objects in conjunction with a RISC processor, provides a real-time classification. Depending on the configuration of the architecture extension, 3 to 12 look-up tables are required for a Xilinx Virtex-5 FPGA implementation.

This paper presents an account of how I developed the Dialogos approach to practical philosophy through action inquiry research. Core perspectives, traditions and purposes involved in the action…. Streptomyces coelicolor contains paralogous versions of seven ribosomal proteins S14, S18, L28, L31, L32, L33, and L36 , which differ in their potential to bind structural zinc. Zur controls the expression of three transcriptional units including rpmG2, rpmE2, rpmB2, rpsN2, rpmF2, and possibly rpsR2.

Zur also controls the expression of the znuACB operon, which is predicted to encode a high-affinity zinc transport system. Zinc-responsive regulation of alternative ribosomal protein genes in Streptomyces coelicolor involves zur and sigmaR. We show that the level of expression of four transcriptional units encoding C - proteins is elevated under conditions of zinc deprivation.

Surprisingly, the zinc-responsive control of the rpmG3-rpmJ2 operon is dictated by sigma R , a sigma factor that was previously shown to control the response to disulfide stress in S. The induction of sigma R activity during zinc limitation establishes an important link between thiol-disulfide metabolism and zinc homeostasis. Strom hinausgehen.

The 15th volume of the Acta Historica Astronomiae is at the same time the fifth collection of essays on the history of astronomy Beitraege zur Astronomiegeschichte, Band 5 , edited by the historians of astronomy W. Besides a few short notices and book reviews, the book contains 11 major articles, which deal with astronomical topics covering the time from the 16th to the 20th centuries.

The first article, on the analysis and interpretation of historical horoscopes as a source of the history of science, is based on the inaugural lecture of its author, Guenther Oestmann. After a general introduction, which deals with the principles of horoscope making, the author discusses the horoscope of Count Heinrich Ranzau , the Danish governor of Schleswig-Holstein, who was a friend of Tycho Brahe. Oestmann shows that the astronomical-mathematical basis of such a horoscope can be reconstructed and interpreted.

However, it is hardly possible to gain an insight in the process how the interpretation of a horoscope was done in detail. The second and third articles, by Franz Daxecker, deal with Athanasius Kircher and Christoph Scheiner, two catholic astronomers of the 17th century. Kircher's Organum Mathematicum is a calculating device that can be used in the fields of arithmetic, geometry, chronology, astronomy, astrology and others. The author provides extracts of the description of the Organum taken from a book by Caspar Schott, which deal with chronology and astronomy.

A photograph of the Organum indicates that this tool consists of a set of tables glued on wooden or cardboard, but details of its contents and applications remain pretty obscure for the reader - a few elaborated examples would have been helpful. The second paper deals with the life of Christoph Scheiner SJ, the co-discoverer of sunspots next to Galileo , after leaving Rome in - the year of the Galileo trial.

Scheiner spent his later years in the Austrian and. Extrakte auf Basis von Viscum album L. Parental stress is increased in clinical contexts e. In addition, parental stress can result in a biased parental perception of child's behavior and emotions. As expected, increased EBSK scores were overrepresented in the clinical sample.

In both samples stressed parents reported having children with more behavioral and emotional problems. Children of stressed parents in turn reported significantly less problems than their parents did. The rating of independent third persons, e. Restrictions in methodology and conclusions for practice are discussed. Zur Schaffung einer umfassenden benutzerfreundlichen und nahtlosen IT-Infrastruktur ist die Beteiligung aller organisatorischen Einheiten und Ebenen erforderlich.

Jedes Individuum wurde eindeutig am individuellen Strophentypenrepertoire identifiziert. Der Wandel des Dialektes erfolgt graduell in Raum und Zeit. Daher sind keine scharfen Dialektgrenzen anzutreffen. Trotz dieser Tatsache markieren die etablierten Strophentypen die Population. Untersuchungen zur Entwicklung von Satellitengalaxien. Balken und 3 ein oft verdeckter Balken. Hauptaugenmerk ist das unterschiedliche Verhalten der Komponenten.

Equilibrium models of one- and two-component satellite galaxies are created. The tidal influence of the Milky Way, which is modeled as a rigid external potential, is examined. A first set of simulations adopting originally spherically-symmetric, one-component satellites show that after elliptical deformation, a bar and tails of unequal length arise which change their morphology cyclically. By considering comparative simulations, the following phenomena are discovered: 1 High-density regions in the tails, 2 low-density zones around the core or bar, 3 an often concealed bar.

The overall morphology as function of time is analysed. The particles are lost from the core via the bar and move along certain morphologically characteristic structures into the tails. After deducing general quantities of the multi-component King model, three stable standard models of two-component satellite galaxies with different distributions of dark and visible matter are found. These models have a mass ratio of for baryonic to dark matter. Without restriction to the universality of the results, the Large Magellanic Cloud was taken as basic prototype for these models.

To choose the proper orbits, the tidal radius of the three-component model of the potential of the Galaxy is calculated both analytically and numerically. Then the simulations are analysed with the different behaviour of the components being the main focus of interest. Main results: 1 It is possible to detach a large fraction of dark matter but only a small amount of visible matter. Dark and visible matter may form different morphological structures. Some of these effects are just projection effects.

Duricrust fragments are higher in S than fines, but samples from both landing sites are surprisingly similar. We suggest that Martian surface materials are aeolian deposits of complex mixtures of weathering products of maficultramafic rocks, possibly consisting of iron-rich clays, sulfates, iron oxides, carbonates, and chlorides. Zur Biologie des marinen Heterotardigraden Tetrakentron synaptae. Eggs and juveniles were found only in June and July, adults only from May to October. There are vagile males and stationary dwarf males. The dorsoventrally flattened body, an enlarged slimy epicuticle in females and dwarf males, the full set of claws also in juveniles, and the anus, which is in a dorsocaudal position, are indicative for an epizoic, sessile life.

There is strong evidence that T. Zur Biologie von Paramphiascella fulvofasciata Copepoda, Harpacticoida. All developmental stages of P. The feeding of the nauplii is advanced by a marginal setule-crest of the labrum which prevents food-particles from being swept away. The oral appendages of the copepodites circumscribe a frustal space ventral to the mouth which facilitates uptake of food-particles.

The nauplii are not able to swim and perform stalking movements with their antennal endopodites. Good swimming ability as well as digging-in-behaviour and negative phototaxis of the copepodites indicate epi- as well as inbenthic mode of life. Several life-cycle characters are described.


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Precopula lasts ca. The number of nauplii per egg double -sac amounts to 25 The whole developmental period lasts 28 days. The maximal lifespan in the laboratory is days. Sex-ratio is almost balanced. Females produce egg-sacs more than 3. Seasonal effects on reproductive activity have not been detected in laboratory cultures. Zur Biosynthese von Phenylalanin und Tyrosin. With the discovery of arogenic acid two new pathways for the biosynthesis of phenylalanine and tyrosine have been revealed.

The occurrence of two, three, or four pathways for the biosynthesis of phenylalanine and tyrosine in microorganisms and plants may be a useful tool for taxonomic classifications. Investigations on enterobacteriaceae, pseudomonads, flavobacteria, streptomycetes, archaebacteria, and on Sphaerotilus, Trichococcus and Leptothrix species from bulking sludge are described. The possible role of arogenate in the evolution of the pathways for tyrosine and phenylalanine biosynthesis is discussed. Es gibt keinen Grund, einer Schwangeren mit Lungenembolieverdacht eine notwendige radiologische Diagnosesicherung vorzuenthalten.

Viele Tests - viele Fehler? Bildgebende Verfahren haben sich in den letzten Jahren einen festen Platz in der Medizin erobert und die medizinische Forschung und Diagnostik revolutioniert. Bildgebende Verfahren sind ohne Mathematik undenkbar, von der Bildrekonstruktion aus den gemessenen Signalen, bis hin zur Auswertung der Bildinformation. Dadurch werden diagnostische Entscheidungen erschwert. Diagnostik von Kontingenzerfahrungen in der fruehen Kindheit. Forschungsbericht Rapport Scientifique. Methods of Social Contingency Analysis.

FB Nr. Written in German, this article demonstrates the influence of different types of contingency information on the development of infant's locus of control and causal attribution, and discusses empirical models for calculating contingency parameters of the microsocial environment of infants, toddlers, and preschool children. Models discussed include:…. The sperm cells of Patella coerulea Patellacea , Monodonta turbinata, and Gibbula tumida Trochacea were investigated by means of transmission electron microscopy.

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Their head contains an apical acrosome and a roundish nucleus followed by 4 or 5 mitochondria and a centriolar apparatus which consists of two centrioles, one of which bears a flagellum. The sperm cells of Monodonta and Gibbula are very similar to each other and differ mainly in size; Patella exhibits more differences very small acrosome, subacrosomal space, variable number of spherical mitochondria origin of spermic dimorphism? The development of the sperm cells shows no peculiarities.

Planungsmodelle und Planungsmethoden. Anhaltspunkte zur Strukturierung und Gestaltung von Planungsprozessen. The topic of this article ist the question, in which phases oft he political planning process planners apply their methodological set of tools. That for the results of a research-project are presented, which were gained by an examination of planning-cases in learned journals.

Firstly it is argued, which model oft he planning-process is most suitable to reflect the regarded cases and how it is positioned to models oft he political process. Thereafter it is analyzed, which types of planning methods are applied in the several stages oft he planning process. The central findings: Although complex, many planning processes can be thouroughly pictured by a linear modell with predominantly simple feedback loops. Even in times of he communicative turn, concerning their set of tools, planners should pay attention to apply not only communicative methods but as well the classical analytical-rational methods.

They are helpful especially for the understanding of the political process before and after the actual planning phase. Zeitspiel ist keine Alternative - Warum der Wandel zur Pflicht wird. Die Energiewelt wird durch den digitalen Wandel nicht verschont bleiben. During the increasing dissemination of renewable energy sources the potential and actual interference effects of wind turbine plants became obvious.


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Turbines reflect the signals of weather radar and other radar systems. As a result, building permit is refused for numerous new wind turbines, as the potential interference can not be reliably predicted. As a contribution to the improvement of this predictability, measurements are planned which aim at the high-frequency characterisation of wind energy installations. In this paper, a cost-effective FMCW radar is presented, which is operated in the same frequency band C-band as the weather radars of the German weather service. Here, the focus is on the description of the hardware design including the considerations used for its dimensioning.

Discusses a German frequency list of 1, to 2, scientific words, which is being developed, and the importance of learning word-building principles. Substantive and adjective suffixes are listed according to frequency, followed by remarks on copulative compounds, with examples and frequency ranking, and, finally, prefixes. Text is in German. In the Federal Republic of Germany there have in recent years been many varied encounters between Germans and representatives of other cultures, particularly those from Third World countries.

These have increasingly been organized with an awareness of global interdependence and have as a result opened the door to the influence of foreign cultures and to an unmistakeable movement in the direction of a multicultural society. An intercultural pedagogical approach and didactic theory are faced with the task of resolving the consequent problems related to education and training. The author firstly attempts to systematize as a typology the practice of learning as it occurs in intercultural encounters in so far as this relates to the Federal Republic of Germany.

Grundvoraussetzungen herzchirurgischer Einheiten zur Behandlung von Patienten mit angeborenen Herzfehlern. This document defines fundamental structures of congenital cardiac surgery departments in Germany. In Germany, pediatric cardiology and cardiac surgery facilities caring for patients with congenital cardiac defects are subject to certain regulations. For example, in the Federal Joint Committee implemented the resolution on Quality Assurance Measures in the Provision of Cardiac Surgical Care for Children and Adolescents directive congenital cardiac surgery which regulates structural and process quality compulsorily.

To date, fundamental and considerable differences of the respective departments persist.

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Congenital cardiac surgery departments have to provide the whole spectrum of the cardiac surgical therapy from the neonate to the adult with congenital cardiac defects with the exception of heart transplantation continuously and with the appropriate experience. Furthermore, the departments have to prove their constant scientific activity and ensure that they facilitate education and training for the specialty certification in cardiac surgery.

The responsible surgeons of all congenital cardiac surgery departments commit to participate in the currently voluntary national quality assurance for congenital cardiac defects of the GSTCVS and the GSPC and perform an individual surgical outcome assessment and risk stratification.

This is supplemented by the willingness for external certification specific to the individual and the facilitation of peer review procedures for quality assurance purposes. Additional measures, such as collaboration in clinical research and ongoing interdisciplinary education and training, are preferable. A multiple regression analysis showed the interrelationships between the parameters measured. Tidal influences on zooplankton and seston dry weight could be observed. At low tide, the amount of zooplankton not counting the harpacticoid copepods declines and the number of harpacticoid copepods rises as does the seston dry weight too.

The chlorophyll-a content is a function of the phytoplankton-nutrients. An increase in chlorophyll-a leads to a decrease in nitrogen and silicate concentrations. The availability of nutrients is influenced by temperature, salinity and the tidal cycle. The amount of oxygen is dependent on water temperature and seston dry weight. High water temperatures and a high seston content lead to a decrease in oxygen concentrations. The reasons for creating international auxiliary languages, such as Esperanto, are examined.

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The study of the synthesis of such languages is considered useful for linguistic theory. Available from Humanities Press, Inc. In the context of an application for a shale gas exploration license including hydraulic fracturing, the Geological Survey of Hessen HLNUG has grouped and ranked structural geological regions in terms of their shale gas potential and the function of overlying rocks as barriers.

Tectonic and structural features as well as the type of reservoir have been examined. Rock units overlying the shale gas layers have been classified as hydrogeological units and divided into aquifers and hydraulic barriers. Possible effects on drinking water abstraction facilities, mineral springs and water for industrial use have also been estimated, followed by an analysis of competing requirements for land use.

Tokamak und Stellarator - zwei Wege zur Fusionsenergie: Fusionsforschung. Parallel soll die in Greifswald entstehende Forschungsanlage Wendelstein 7-X die Kraftwerkstauglichkeit des alternativen Bauprinzips der Stellaratoren zeigen. Knowing the hydraulic conductivity K is a precondition for understanding groundwater flow processes in the subsurface. Numerous laboratory and field methods for the determination of hydraulic conductivity exist, which can lead to significantly different results.

In order to quantify the variability of these various methods, the hydraulic conductivity was examined for an industrial silica sand Dorsilit using four different methods: 1 grain-size analysis, 2 Kozeny-Carman approach, 3 permeameter tests and 4 flow rate experiments in large-scale tank experiments. Due to the large volume of the artificially built aquifer, the tank experiment results are assumed to be the most representative. Hydraulic conductivity values derived from permeameter tests show only minor deviation, while results of the empirically evaluated grain-size analysis are about one magnitude higher and show great variances.

The latter was confirmed by the analysis of several methods for the determination of K-values found in the literature, thus we generally question the suitability of grain-size analyses and strongly recommend the use of permeameter tests. Caudal regeneration was investigated in decerebrate Anaitides mucosa and in brain-intact individuals. Both groups show an identical capacity to regenerate lost caudal segments. Furthermore there is no difference in males and females. At the same time degeneration of most oocytes occurs.

Mikrobielle Kurzzeitteste zur Bestimmung der mutagenen Potenz chemischer Substanzen. During the last 20 years it became much more interesting to test new chemicals as fast as possible for their carcinogenic potency. Therefore new test models were developed. Mutagenicity seems to be one sign for carcinogenicity. Therefore test systems using microorganisms were studied which are influenced by mutagenic substances. The yeast Saccharomyces cerevisiae was introduced some years ago and finally the Neurospora crassa system serves as an additional test to define exactly the localisation of mutations.

The tests and their problems are discussed. Chirurgie angeborener Herzfehler. In Deutschland werden jedes Jahr etwa 6. Dies kann beispielsweise bei einer nicht korrigierbaren angeborenen Fehlbildung notwendig sein, bei der lediglich eine funktionelle Herzkammer vorhanden ist z. Hierbei muss eine prothetische Verbindung zur Lungenstrombahn in der Folgezeit entfernt werden. Die Hiatushernie war nach einer dieser Behandlung endoskopisch nicht mehr nachweisbar.

Prospektive kontrollierte klinische Studien sind notwendig, um den Stellenwert von osteopathischen Behandlungen bei GERD mit Hiatushernie zu untersuchen. Published by S. Die Mechanismen werden derzeit weiter bis hin zur molekularbiologischen und epigenetischen Ebene erforscht.

Momentan existiert jedoch noch ein erheblicher Mangel an Translation zwischen diesen Forschungserkenntnissen und deren Anwendung in der klinischen Versorgung. Groundwater pollution with organic contaminants remains a world-wide problem. Before selection of any remediation technique, it is important to pre-assess contaminated sites with respect to their hazard.

These approaches differ from each other in source geometry, model domain orientation, and in the consideration of bio chemical reaction within the domain. In this communication, we provide details about the development of "NAFLA", its possible usage and information for users. The tool is especially designed for application in student education, by authorities and consultants.

Von den Flitterwochen zur distanzierten Partnerschaft. A recent wave of takeovers by private equity investors and foreign investors from emerging economies has challenged German executives. In cases of friendly takeovers, as described in this study, managers at first appear to extend a cosmopolitan welcome to the new owners. However, further analysis of structural hermeneutics reveals latent normative professional ethics of managers which lead to practices of distancing, in particular from young investors from China, India, and Russia.

Traces the history of sociolinguistic studies in West Germany from the early nineteenth century with Humboldt and reports on the state and purposes of sociolinguistic studies in present-day Federal Republic of Germany. Dass diese Entwicklung noch lange nicht abgeschlossen ist, zeigt die derzeitige Diskussion zum Thema Web 2. The estimation of groundwater recharge in water-limited environments is challenging due to climatic conditions, the occurrence of deep unsaturated zones, and specialized vegetation. We critically examined two methods based on stable isotopes of soil water: i the interpretation of natural isotope depth-profiles and subsequent approximation of recharge using empirical relationships and ii the use of deuterium-enriched water 2H2O as tracer.

Numerous depth-profiles were measured directly in the field in semiarid Namibia using a novel in-situ technique. Additionally, 2H2O was injected into the soil and its displacement over a complete rainy season monitored. The results of this study fortify the suitability of water stable isotope-based approaches for recharge estimation and highlight enormous potential for future studies of water vapor transport and ecohydrological processes. This paper reports experience with direct quantitative trace element determinations in powdered geological samples by nameless atomic absorption spectroscopy.

Two methods were explored. The first one is based on the production of a sample aerosol by laser radiation in a specifically designed sample chamber and the subsequent transport of the aerosol into a graphite tube, which has been preheated to a stable temperature. This technique is suited for a large range of concentration and is relatively free from matrix interferences. The described sample chamber can be also used in combination with other spcctroscopic techniques.

The second method explored permits the quantitative determination of trace elements at very low concentrations. Essentially an accurately weighed amount of sample is placed on a graphite rod and introduced into a graphite furnace by inserting the rod through the sample injection port.

Atomization takes place also under stable temperature conditions. Acidic microenvironmental conditions combined with large hypoxic areas are ubiquitous hallmarks of most solid tumors. They result from a poorly organized vascularization and a deviant energy metabolism. There is convincing evidence supporting the hypothesis that such physico-chemical conditions promote the microevolution of malignant cells, inhibit the cellular immune response, and favor tumor cell invasion.

In agreement with published data, our cell biological analyses and computer simulations indicate that treatment schemes which restore a tumor microenvironment reflecting that one found in normal tissues might improve the efficiency of immunotherapies and classical methods for cancer treatment. We suggest that the tumor microenvironment could be effectively monitored and manipulated by means of silicon-based feedback bioactuators which are controlled by integrated microsensors.

In principle, miniaturized bioactuators can be implanted directly at the sites of inoperable tumors and metastases where they function as a "pH clamp" and thereby can reconstitute normal physico-chemical conditions. Drug application could be precisely controlled by an integrated microprocessor. Our paper summarizes the current state of development of microsensor-based feedback bioactuators and outlines possible applications in biophysical cancer treatment.

This book collects about 15 papers most of them by one single author on Einstein and the history of general relativity GR and the foundations of relativistic cosmology. The matter not only deals with Einstein and his times, but also with pre-GR ideas, and with the interplay of Einstein and his colleagues opposing as well as supporting personalities. As the title indicates, all papers are written in German, but they include comprehensive Abstracts both in German and English. The book is illustrated with quite a number classical - but also some far more original though not less beautiful - photographs and facsimiles of documents.

The book is edited very well, though the style of references is not quite homogeneous. There is no Index. Hentschel covers Einstein's argumentation for the existence of graviational redshift, and the initial search for empirical support. The error analysis of observational evidence supporting relativistic light deflection is discussed in a paper by P. In particular, H. Duerbeck and P. Flin - in their description of the life and work of Silberstein, who was quite sceptic on the significance of the observational verifications a la Eddington - include the transcription of two most revealing letters by Silberstein to Sommerfeld and to Einstein In the first letter, Silberstein clearly shows his scientific maturity and integrity by scrutinising the observational evidence supporting light deflection, presented at a joint meeting of the Royal Society and the Royal Astronomical Society.

The second letter, which is more a personal letter, includes lots of political references and connotations. Some of Einstein's political views are also revealed by D. Herrmann on the basis of his own correspondence with E. Straus, a collaborator of Einstein's.

Table of contents

In a consequent paper, S. Grundmann gives remarks on Herrmann's contribution and illustrates Einstein's attitude towards Marx, Engels, Lenin and Stalin. Schemmel discusses Schwarzschild's cosmological speculations, and wonders why some people do immediately grasp the meaning and consequence of newly proposed doctrines, whereas the bulk of the contemporaneous scientists respond in a rather low profile. Jung reviews Einstein's contribution to cosmology, leading to the Friedmann-Einstein and Einstein-de Sitter universes with a detailed Appendix on the Friedmann-Lemaitre cosmology , and also presents the cosmological work of Selety, and his correspondence with Einstein.

In a subsequent paper, H. Schmidt comments on Einstein's criticism on de Sitter's solution of the Einstein field equations. Controversies with Einstein are elaborated by G. Singer on Friedmann and by K. Roessler on Lemaitre. Renn and T. Sauer discuss Mandl's role in the publication history of Einstein's papers, notably Einstein's short paper on gravitational lensing.

Finally, the book concludes with a contribution by D. Herrmann about the relationship between Einstein and Archenhold Observatory where Einstein gave his first Berlin popular lecture in , the transcription of H. Treder's public address at the Einstein memorial plaque, and an inventory list of about 50 Einstein memorabilia - monuments, busts, plaques - compiled by W. This book is based on ideas approached in a historical context from the individual perspective of the authors.

It is a real treasure trove of information and basic references on the history of GR, and it also covers quite some grounds with mathematical equations. For many tracer experiments, prior determination of interaction between solid medium and used tracers is of major interest in order to achieve efficient, economic and successful field experiments. In the present study, three different types of batch experiments were performed with three fluorescent dyes Na-Fluorescein, Amidorhodamin G and Tinopal CBS-X and three different rock types sandstone, claystone and limestone , to determine distribution coefficients and reaction kinetics.

All three rock types were analysed for organic carbon content, specific surface area and mineralogical composition to identify the main sorption mechanisms. For all tracers, different sorption properties were found depending on the type of rock. Only Na-Fluorescein showed sorption albeit limited in contact with the sandstones. Regarding reaction kinetics, in most cases, thermodynamic equilibrium conditions were reached after two weeks.

Reforms and Innovations in Estonian Education. Baltische Studien zur Erziehungs- und Sozialwissenschaft. Volume This collection of papers provides a small overview of educational research in Estonia. The papers in the collection treat school reforms since the renewal of independence in , new approaches to teacher training, the implementation of a child-centred approach in school, the achieving of educational aims and other actual topics in education.

In urban areas of the Swiss Alps the use of geothermal energy from several hundred meters depth becomes increasingly important. For this mainly open systems have priority. This work presents the first insights in the prospection and characterisation of the so far unexplored, utilizable, and abundant Aquifer of the Arosa Dolomites. Besides the use of established methods and techniques, such as seismic measurements, an exploration drilling, borehole geophysical measurements, and pumping tests, the application of the KARSYS-approach for geological and conceptual hydrogeological 3D-modelling of the aquifer is illustrated.

In addition, the development of a viewer for 3D-visualization of drillings is documented. The hydrogeological and metrological approaches allow a lithological facies differentiation of the Arosa Dolomites, and a differentiation of the fractured and karstified areas within the aquifer. The results represent the basis for advanced findings optimizing and risks minimising exploration and drilling planning, and for sustainable utilization planning. Studien zur Erwachsenenbildung, Band These 17 articles on different subjects of the broader theme "lifelong learning" represent the latest results of the discussions of the Vocational Education and Culture Research Network.

An introduction Klaus Harney et al. This collection includes eight papers authored by Germans on adult education programs in Cleveland, Ohio, and eight papers authored by Americans about adult education programs in the Federal Republic of Germany as well as German and English introductions to the collection.

The following papers are included: "Neue Wege in der…. Describes the purpose, structure and application of this monolingual verb lexicon, which indicates the morphosyntactic environments of the most common German verbs. Mention is made of the forthcoming valence lexicon.

The book is for teachers and textbook writers. Learning to read foreign technical texts requires a a minimum vocabulary and b effective drill.